Instantiation of incentive value and movement invigoration by distinct midbrain dopamine circuits (Saunders et. al)

Cool paper:

Instantiation of incentive value and movement invigoration by distinct midbrain dopamine circuits

Never stop reading! This paper is pretty representative of the research I’d like to be doing within the next several years. Haven’t finished reading it but am enjoying it & wanted to post here. I’m noticing that when research articles or readings are really tremendously exciting I come to ramble about them before actually finishing them.

The lead researcher on this study is a dude by the name of Benjamin T. Saunders. He got an undergrad degree from West Virginia University, a PhD at the University of Michigan, and then did some postdoc research at UCSF and then Johns Hopkins. He’s now opened a lab at the University of Minnesota that came to my attention via a random listserve email from the U of M. They’re doing cool stuff related to dopamine, reward, etc. & I want to keep track of it. The techniques they’ll be using in the lab (EG optogenetic signalling) are things I’ve read about in class but never really read about in real life. And if they’re doing it over at the U that makes me curious about going to take a look at their lab.

So what’s with distinct midbrain dopamine circuits? Why should we care?

 

≈[almost equal to]

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From September 15th – October 22nd of 2017 a fantastic play is show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, show, showing at the Pillsbury Theatre in Minneapolis. You should go. [what would it be like to do the same show 26 times in 5 weeks? whoa!]

Self-indulgence seemed to be the theme here.

It was written by Janas Hassen Khemiri and was perhaps the most creepy/dark/effective/funny/great/hedonistic/individual portrayal of money, greed, and desire I have ever witnessed. The space at the theatre was simple, and the actors – often embodying various attitudes or inner urges experienced by the actual “scripted”/”real” characters – flowed through and beyond the set with humor and ease. One single actor might represent three neighborhood goofballs over the span of 2 minutes – at another moment, 2 actors might represent 1 single goofball’s inner dialogue. Very cool work & had me scribbling on my mini-paper-pad thing excessively throughout the show.

DESIRE. This goal-oriented intoxicating desire reminded me for the entire 1 hour and 45 minutes of the nucleus accumbens and VTA. The performance felt like a clear demonstration of our inner desires for wealth and class and fancy items – walk in closets, perfume, champagne – and thus connoted the reward systems we all have in common. Of course those reward systems are best characterized as biological, as they operate on entirely passive, predictable, and commonly inherited forces. Much of the melancholy came from divisive attitudes and circumstances, and the passing of judgment. Greedy folks blaming other greedy folks for being greedy.

Are we all screwed? Maybe not. The consistency of this self-indulgence and other-blaming is what offered at least some comedic redemption for each character. If we’re all united in our humanity by greed it perhaps opens up the conversation about what to do about it. [The program offers several discussion questions, one of which is Do you identify with any of the characters? I identified with all of them, down to the yucky details.]

So what’s with greed? What’s with money? Thanks to the theatre & the playwright for getting at least my brain and a few others to keep wondering. Capitalism is our mutual problem as a society (especially in America), and maybe to be unified and identified as automata who are equally enticed by pleasure is the first step towards rewiring our nature.